BU-224 is a Putative I2 antagonist; and a high affinity ligand for the imidazoline I2 binding site (Ki = 2.1 nM). BU224 reverses cognitive deficits, reduces microgliosis and enhances synaptic connectivity in a mouse model of Alzheimer's disease.

Product information

CAS Number: 205437-64-5

Molecular Weight: 233.70

Formula: C12H12ClN3

Chemical Name: 2-(4, 5-Dihydroimidazol-2-yl)quinoline hydrochloride

Smiles: Cl.C1CNC(=N1)C1=CC=C2C=CC=CC2=N1

InChiKey: DDFHQXAQWZWRSQ-UHFFFAOYSA-N

InChi: InChI=1S/C12H11N3.ClH/c1-2-4-10-9(3-1)5-6-11(15-10)12-13-7-8-14-12;/h1-6H,7-8H2,(H,13,14);1H

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: To be determined

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 ^oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 ^oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

References:

1. Mirzaei N, Mota BC, Birch AM, Davis N, Romero-Molina C, Katsouri L, Palmer EOC, Golbano A, Riggall LJ, Nagy I, Tyacke R, Nutt DJ, Sastre M. Imidazoline ligand BU224 reverses cognitive deficits, reduces microgliosis and enhances synaptic connectivity in a mouse model of Alzheimer's disease. Br J Pharmacol. 2021 Feb;178(3):654-671. doi: 10.1111/bph.15312. Epub 2020 Dec 27. PMID: 33140839.
2. Kotagale N, Dixit M, Garmelwar H, Bhondekar S, Umekar M, Taksande B. Agmatine reverses memory deficits induced by Aβ1-42 peptide in mice: A key role of imidazoline receptors. Pharmacol Biochem Behav. 2020 Sep;196:172976. doi: 10.1016/j.pbb.2020.172976. Epub 2020 Jun 26. PMID: 32598984.
3. Cobos-Puc LE, Sánchez-López A, Centurión D. Pharmacological analysis of the cardiac sympatho-inhibitory actions of moxonidine and agmatine in pithed spontaneously hypertensive rats. Eur J Pharmacol. 2016 Nov 15;791:25-36. doi: 10.1016/j.ejphar.2016.08.017. Epub 2016 Aug 24. PMID: 27565220.

Products are for research use only. Not for human use.